Psychoactivity is a broad term for the action of the many chemicals that affect the function of the brain. There are many classes of these substances, such as stimulants, anesthetics, sedatives, narcotics, depressants, antidepressants – and also psychedelics. The mechanism of action of such drugs always involves psychoneurological systems. Medically valuable psychoactive drugs are most often discovered in animal behavior experiments, and finding out how the drugs work frequently calls upon sophisticated research using appropriately radio-labeled synthetic samples. But for the past four decades, I have studied psychoactive drugs at the far end of the spectrum: those that affect the mind. These substances are usually discovered by people experimenting on humans. Rats have brains, and we can remove them, cut them into slices, and see where experimental drugs have gone – but I am not sure rats have what most people think of as minds.It should be stated outright that the uses … [Read more...] about Abused Substances
Lsd effects on the brain
One algorithm makes you smaller, and one makes you tall. But the ones the FDA gives you won’t do anything at all – not without a prescription, anyway.Welcome to the brave new world of electrotherapy stimulation. What may have once been limited to experimental research labs is about to become as common as Prozac – and that should have Big Pharma scared. Mood alteration is becoming as simple and inexpensive as a battery-powered handheld device with two little electrodes you strap on your head. Sit there for 20 minutes receiving gentle, barely perceptible pulses, and cure your anxiety, insomnia, PTSD, depression, bipolar disorder, and more.Mood alteration is becoming as simple and inexpensive as a battery-powered handheld device.This much isn’t speculation, but FDA-verified, double-blind, peer-reviewed fact. Doctors at Mt. Sinai Beth Israel in New York used neurostimulation not only to successfully treat bipolar depression, but to do so with zero side … [Read more...] about Dial 1 for euphoria: What happens when we can zap our brains into any mood?
Your brain on acid looks about as trippy as your hallucinations on acid. For the first time ever, scientists have managed to look inside the mind of an LSD user, all thanks to modern scanning technology and a few volunteers who got high for the sake of science. Researchers from Imperial College London have now visualized the effects of the psychedelic Lysergic acid diethylamide, better known as LSD or acid.To complete their study, scientists asked 20 healthy volunteers to pay two visits to clinics on different days. On the first day, they were given a “common” oral dose of a 75-microgram LSD injection. On the second day, they received a placebo. Three different brain imaging techniques were then employed to analyze blood flow, brainwaves, and functional connections both within and between brain networks. The results speak for themselves.The scans clearly indicate the significant hallucinogenic effects LSD has on the brain, lending credence to the … [Read more...] about This is your brain on LSD
Have you ever wondered what it’s like to see sound or smell color? It sounds absurd, but believe it or not, it’s totally possible for people with synesthesia — a term used to describe the simultaneous experience of two connected senses. Most people will never experience synesthesia unless they ingest large amounts of hallucinogenic drugs — but now, thanks to aerospace engineer Zachary Howard, you don’t have to eat half a blotter of LSD to achieve the effect. Howard has designed a DIY synesthesia mask that you can make on your own. With some cheap hardware and basic programming skills, you’ll be able to smell color just like a synesthete.Howard’s mask actually starts with a color sensor at his fingertip. The sensor registers the color of whatever Howard touches, and sends that data to an Intel Edison Chip. The chip analyzes the detected color in order to break it down into the three components that computers use to understand any … [Read more...] about Incredible DIY synesthesia mask gives you the ability to smell colors — without taking drugs
Drug Discovery One way or another, many psychiatric drugs work by binding to receptor molecules in the brain that are sensitive to the neurotransmitter dopamine, a chemical signal that is central to how our experiences shape our behavior. But because scientists still don't understand the differences between the many kinds of dopamine receptors present on brain cells, most of these drugs are "messy," binding to multiple different dopamine receptor molecules and leading to serious side effects ranging from movement disorders to pathological gambling.Now, researchers at UC San Francisco, the University of North Carolina-Chapel Hill, and Stanford University report a major step forward towards designing more powerful psychiatric drugs with fewer side effects.As reported online on October 19, 2017 in Science, the team has determined ("solved" in the terminology of structural biology) the crystal structure of a specific dopamine receptor called D4 at an incredibly high resolution - the … [Read more...] about Key Psychiatric Drug Target Comes into Focus